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Recently, I identified myself in a wellness funk. I hadn’t exercised in a whilst, and most of my meals were DoorDash deliveries. Just after weeks of sitting on the sofa and having cheese-included carbs, I was all set for a wellness reboot. So, I achieved …
Former smokers nonetheless facial area greater disease and untimely demise threats, but they were being able to slice down on that mortality hazard by sticking with a balanced life style, according to a possible cohort review. Among persons who applied to smoke, increased total adherence …
Although menopause is a naturally occurring transition, it can often cause numerous unpleasant symptoms in women — primarily due to declining female hormone levels.
According to the
In addition, research suggests that the natural decline in estrogen that occurs with menopause may also increase a woman’s risk of
Treating menopause-related symptoms and negating disease risk in postmenopausal women generally involves hormone replacement therapy (HRT). However, research from 2021 shows that HRT can increase the risk of cardiovascular disease, stroke, and certain types of cancer in some women.
Other
Some reports also suggest that alternatives such as medical cannabis may be useful for treating menopausal symptoms. Still, the safety and effectiveness of using cannabis for menopause are not fully understood.
Since therapies for menopause are limited and may carry unwanted health risks, better options are needed for those seeking relief from their symptoms.
A Rutgers University mouse study, recently published in the journal Frontiers in Pharmacology, has found evidence that cannabidiol (CBD) may have therapeutic potential for relieving symptoms of estrogen deficiency, and potentially offer benefits for individuals experiencing menopause and postmenopause. While the evidence seems promising, more research is needed in humans before CBD should be considered a safe and effective treatment.
To evaluate CBD’s effect on menopause-related symptoms and disease risk, Rutgers University scientists divided estrogen-deficient mice into two groups.
For over 18 weeks, the researchers fed one group a diet containing CBD isolate (96–99{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} purity) from Bluebird Botanical (Louisville, CO). Mice in the other group were fed the same diet without CBD.
After the treatment period ended, the mice underwent several tests, including metabolic tests, gene expression tests, bone density assessments, and gut microbiota analysis.
The scientists found that mice in the non-CBD-treated group developed symptoms similar to postmenopausal human females. According to a press release, these include:
However, mice treated with CBD showed significant improvements in several areas. According to the study, the CBD-treated mice had:
The scientists said these results indicate that CBD positively impacts the immune system and gut microbiota. And these effects may offer protection against menopause-related inflammation, bone loss, impaired energy metabolism, and glucose intolerance.
“In agreement with other studies that have documented the anti-inflammatory effect of CBD, we found that CBD treatment of estrogen-deficient mice led to reduced expression of inflammatory mediators in bone and intestinal tissues. We also observed that CBD altered the fecal gut microbiota,” senior study author Diana Roopchand, PhD, assistant professor in the Department of Food Science of the Rutgers School of Environmental and Biological Sciences (SEBS), told Healthline.
“Notably, estrogen-deficient mice treated with CBD showed increased relative abundance of Lactobacillus species compared to untreated controls. Other studies have reported that Lactobacillus, a well-known probiotic, can protect against bone loss and decrease markers of inflammation in the gut, bone, and circulation,” she added.
Roopchand also explained how CBD might have caused these effects.
“CBD is known to interact with several receptors or targets in multiple tissues,” she said.
“In this first study, we analyzed gene expression of just four CBD receptors in femur tissue and found that, compared to untreated animals, estrogen-deficient mice treated with CBD had an increase in endocannabinoid receptor CB2. Stimulation of CB2 receptor is associated with less bone resorption. Ours is the first study of CBD in a murine model of postmenopause — therefore, more research is needed to better define mechanisms of action.”
CBD, or cannabidiol, is a derivative of the cannabis plant that does not contain the psychoactive compound tetrahydrocannabinol (THC). It is an alternative to medical cannabis that does not produce a high.
“Cannabidiol (CBD) and tetrahydrocannabinol (THC) are both natural cannabis compounds known to affect the body’s endocannabinoid system but in different ways,” Dr. Amir Marashi, board certified cosmetic gynecologist and pelvic pain specialist and Founder at Cerē, told Healthline.
“As an extract, CBD can be added to ingestibles, topical creams [or] gels, used as a medicinal tincture, and more,” he said. “Many [people] appreciate that it provides some of the calming, pain relieving benefits of cannabis without the associated THC ‘high’ feeling.”
Dr. Lewis Jassey, DO, medical director at Leafwell, told Healthline that CBD’s effectiveness in managing the symptoms of menopause is difficult to prove, but it “does have a broad impact on a range of receptor systems that can help manage pain, inflammation, and cramps, including serotonin receptors, dopamine receptors, and opioid receptors.”
“CBD also inhibits the degradation of anandamide, which can help improve mood and help relieve pain and anxiety. CBD may also help relieve headaches,” Jassey explained.
According to Jassey, side effects of CBD might include:
“But these are not common at low to moderate doses and can be less severe than the side effects of antidepressants and NSAIDs like ibuprofen,” he said.
Although menopause is a natural process, it can cause unpleasant physical symptoms and may negatively impact mental health. In addition, the decline in estrogen associated with menopause can also increase the risk of certain health conditions.
Treating the symptoms of menopause is generally limited to HRT or non-hormone-containing prescription medications. But these options can have health risks and may not be appropriate for everyone.
However, this latest mouse study from Rutgers University highlights several potential health benefits CBD may have for postmenopause. Still, more research is needed to determine if CBD has a therapeutic role in treating postmenopause-related conditions in humans.
A federal jury convicted a former CEO of a overall health clinic for defrauding the Louisiana Medicaid System about many a long time. According to courtroom files and evidence presented at demo, Victor Clark Kirk, 73, of Baton Rouge, Louisiana, was the CEO of St. …
By focusing on broader incident response training efforts – which involves medical, operational and other teams – as part of overall emergency preparedness programs, healthcare providers will be better positioned to maintain and deliver patient care when systems are breached and potentially disabled following a …
Females with a record of diabetes in pregnancy can continue to minimize their possibilities of building sort 2 diabetes by adopting a balanced life-style, these types of as having nutritious, halting using tobacco, working out on a regular basis, and not currently being overweight, finds a analyze in The BMJ now.
The success present that ladies who adhered to 5 crucial lifestyle factors—healthy body weight, large-high quality diet regime, standard physical action, average liquor intake, and not smoking—had a 90{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} lower hazard of the dysfunction in comparison with gals who did not adhere to any, even amid these who have been overweight or overweight, or were being at larger genetic danger of style 2 diabetes.
It is broadly identified that a nutritious life-style is related with a reduced chance of acquiring form 2 diabetic issues in frequently balanced middle-aged populations.
But significantly less is recognized about no matter whether this also applies to superior-risk ladies with a heritage of diabetes in being pregnant (gestational diabetic issues), and if obesity standing or genetic possibility of sort 2 diabetic issues influence this association.
To fill in these research gaps, researchers evaluated the associations of adherence to exceptional amounts of five modifiable hazard factors—healthy entire body mass index, significant-good quality diet regime, common actual physical exercise, reasonable liquor consumption, and not smoking cigarettes, with the risk of acquiring kind 2 diabetic issues among these women of all ages at large chance.
Their findings are based on details for 4,275 females with a background of gestational diabetes mellitus from the Nurses’ Health and fitness Analyze II with recurring measurements of body weight and way of life things about 28 decades of comply with-up.
The scientists also assessed regardless of whether these associations altered according to obesity status or fundamental genetic susceptibility for sort 2 diabetic issues.
More than an typical 28 years of comply with-up, 924 women created type 2 diabetic issues.
Right after getting account of other big diabetes danger components, the researchers observed that individuals who experienced optimum amounts of all five modifiable things immediately after the index being pregnant experienced a extra than 90{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} reduce risk for creating type 2 diabetic issues in comparison with all those who did not have any.
Each further optimum modifiable element was linked with an incrementally decrease threat of form 2 diabetes. For case in point, women with a single, two, 3, four, and 5 ideal concentrations of modifiable aspects as opposed with none had a 6{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d}, 39{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d}, 68{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d}, 85{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d}, and 92{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} reduced risk, respectively.
And these valuable associations ended up continuously viewed, even among gals who have been obese or overweight or who had better genetic susceptibility to kind 2 diabetes.
This is an observational analyze, so it are not able to establish lead to, and the scientists acknowledge that the info relied on particular experiences, which might have impacted precision. What’s more, the review bundled predominantly healthcare gurus of European ancestry, so the final results may not apply to individuals of other racial or ethnic teams or socioeconomic teams.
On the other hand, strengths contain use of facts from a massive analyze with recurring measurements of wellbeing relevant and behavioral possibility aspects, which will help to better capture extensive expression way of living patterns and decrease measurement error and misclassification.
As these, the scientists say their study “highlights the significant general public well being possibility for the prevention of variety 2 diabetic issues in this higher-hazard populace.”
Poor diet plan associated with greater diabetic issues danger throughout all gradients of genetic danger
Citation:
Healthier lifestyle joined to 90{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} decreased possibility of diabetic issues in vulnerable girls (2022, September 21)
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