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Although menopause is a naturally occurring transition, it can often cause numerous unpleasant symptoms in women — primarily due to declining female hormone levels.
According to the
In addition, research suggests that the natural decline in estrogen that occurs with menopause may also increase a woman’s risk of
Treating menopause-related symptoms and negating disease risk in postmenopausal women generally involves hormone replacement therapy (HRT). However, research from 2021 shows that HRT can increase the risk of cardiovascular disease, stroke, and certain types of cancer in some women.
Other
Some reports also suggest that alternatives such as medical cannabis may be useful for treating menopausal symptoms. Still, the safety and effectiveness of using cannabis for menopause are not fully understood.
Since therapies for menopause are limited and may carry unwanted health risks, better options are needed for those seeking relief from their symptoms.
A Rutgers University mouse study, recently published in the journal Frontiers in Pharmacology, has found evidence that cannabidiol (CBD) may have therapeutic potential for relieving symptoms of estrogen deficiency, and potentially offer benefits for individuals experiencing menopause and postmenopause. While the evidence seems promising, more research is needed in humans before CBD should be considered a safe and effective treatment.
To evaluate CBD’s effect on menopause-related symptoms and disease risk, Rutgers University scientists divided estrogen-deficient mice into two groups.
For over 18 weeks, the researchers fed one group a diet containing CBD isolate (96–99{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} purity) from Bluebird Botanical (Louisville, CO). Mice in the other group were fed the same diet without CBD.
After the treatment period ended, the mice underwent several tests, including metabolic tests, gene expression tests, bone density assessments, and gut microbiota analysis.
The scientists found that mice in the non-CBD-treated group developed symptoms similar to postmenopausal human females. According to a press release, these include:
However, mice treated with CBD showed significant improvements in several areas. According to the study, the CBD-treated mice had:
The scientists said these results indicate that CBD positively impacts the immune system and gut microbiota. And these effects may offer protection against menopause-related inflammation, bone loss, impaired energy metabolism, and glucose intolerance.
“In agreement with other studies that have documented the anti-inflammatory effect of CBD, we found that CBD treatment of estrogen-deficient mice led to reduced expression of inflammatory mediators in bone and intestinal tissues. We also observed that CBD altered the fecal gut microbiota,” senior study author Diana Roopchand, PhD, assistant professor in the Department of Food Science of the Rutgers School of Environmental and Biological Sciences (SEBS), told Healthline.
“Notably, estrogen-deficient mice treated with CBD showed increased relative abundance of Lactobacillus species compared to untreated controls. Other studies have reported that Lactobacillus, a well-known probiotic, can protect against bone loss and decrease markers of inflammation in the gut, bone, and circulation,” she added.
Roopchand also explained how CBD might have caused these effects.
“CBD is known to interact with several receptors or targets in multiple tissues,” she said.
“In this first study, we analyzed gene expression of just four CBD receptors in femur tissue and found that, compared to untreated animals, estrogen-deficient mice treated with CBD had an increase in endocannabinoid receptor CB2. Stimulation of CB2 receptor is associated with less bone resorption. Ours is the first study of CBD in a murine model of postmenopause — therefore, more research is needed to better define mechanisms of action.”
CBD, or cannabidiol, is a derivative of the cannabis plant that does not contain the psychoactive compound tetrahydrocannabinol (THC). It is an alternative to medical cannabis that does not produce a high.
“Cannabidiol (CBD) and tetrahydrocannabinol (THC) are both natural cannabis compounds known to affect the body’s endocannabinoid system but in different ways,” Dr. Amir Marashi, board certified cosmetic gynecologist and pelvic pain specialist and Founder at Cerē, told Healthline.
“As an extract, CBD can be added to ingestibles, topical creams [or] gels, used as a medicinal tincture, and more,” he said. “Many [people] appreciate that it provides some of the calming, pain relieving benefits of cannabis without the associated THC ‘high’ feeling.”
Dr. Lewis Jassey, DO, medical director at Leafwell, told Healthline that CBD’s effectiveness in managing the symptoms of menopause is difficult to prove, but it “does have a broad impact on a range of receptor systems that can help manage pain, inflammation, and cramps, including serotonin receptors, dopamine receptors, and opioid receptors.”
“CBD also inhibits the degradation of anandamide, which can help improve mood and help relieve pain and anxiety. CBD may also help relieve headaches,” Jassey explained.
According to Jassey, side effects of CBD might include:
“But these are not common at low to moderate doses and can be less severe than the side effects of antidepressants and NSAIDs like ibuprofen,” he said.
Although menopause is a natural process, it can cause unpleasant physical symptoms and may negatively impact mental health. In addition, the decline in estrogen associated with menopause can also increase the risk of certain health conditions.
Treating the symptoms of menopause is generally limited to HRT or non-hormone-containing prescription medications. But these options can have health risks and may not be appropriate for everyone.
However, this latest mouse study from Rutgers University highlights several potential health benefits CBD may have for postmenopause. Still, more research is needed to determine if CBD has a therapeutic role in treating postmenopause-related conditions in humans.
Younger people today in the United States are going through a mental overall health disaster. Warnings from the surgeon normal, the American Academy of Pediatrics, the American Psychological Association and other well known organizations, as perfectly as normal news reports, highlight the catastrophe, with moms …
Sharde Gillam , Editor @its_sharr Sharde Gilliam is a focused journalist who enjoys masking enjoyment, fashion, elegance, and is passionate about all factors relevant to Black gals and Black society. She initially joined HelloBeautiful as an intern and slowly but surely labored her way up …
ST. LOUIS — Republican Missouri state Sen. Mike Moon thinks that covid-19 vaccinations, specifically amid youngsters, should really cease until the lengthy-time period consequences are acknowledged. He factors to the study of resources of covid misinformation like America’s Frontline Doctors and Dr. Robert Malone, a visitor on Joe Rogan’s podcast. He himself is not vaccinated.
So, on Feb. 1, he and other senators tanked the nomination of Donald Kauerauf to come to be the state’s future health and fitness director. Kauerauf experienced held the office in an interim potential since September and professed on the report that he was anti-abortion and anti-mandate for masks and vaccinations, all although getting nominated by a Republican governor who is also anti-mandate. But it was not adequate for Moon.
“Missourians really don’t want to be ruled with an iron fist,” Moon explained.
The heartland state’s kerfuffle is one additional instance of political pushback to public well being leadership. A KHN and Linked Push investigation last 12 months uncovered that at minimum 1 in 5 Individuals lived in places that experienced missing their top rated community community overall health official amid a wave of threats to the profession and serious tension that led to firings, resignations, and retirements given that the pandemic commenced. This sort of blows endanger the general public health system’s potential to answer to other difficulties in the long term, general public overall health officers stated.
In Florida, the nominee for that state’s surgeon normal declined five instances to definitively accept in a hearing that covid vaccines function. And the point out overall health division just lately positioned a nearby community wellness formal on administrative leave for encouraging vaccinations amongst his team.
Montana passed a law banning employers — which include in overall health care settings — from demanding vaccinations for covid, the flu, or something else.
A Tennessee legislator threatened the existence of the state professional medical board for warning that physicians could jeopardize their licenses if they unfold covid misinformation.
Serving at the satisfaction of elected leaders is turning out to be “twisted and grotesque” amid serious politicization, mentioned Brian Castrucci, CEO of the de Beaumont Basis, which advocates for community overall health. Governmental public well being leaders are becoming selected dependent on their political ideology alternatively than their scientific and leadership skills, he included.
“This is community health and fitness dying,” he explained. “A darkish age of politics has begun that is choking science.”
More than 50 {b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} of states have rolled back public wellbeing powers all through the pandemic, which industry experts say permanently weakens states’ qualities to guard their constituents’ health and fitness.
“Both the fundamental authorized authorities of public wellbeing, as perfectly as the people who are practising, are staying threatened in methods we have in no way witnessed prior to,” reported Dr. Georges Benjamin, government director of the American General public Overall health Association. He warned that even far more legislative rollbacks would take place this yr throughout the country, as perfectly as court rulings limiting general public overall health authorities.
This stripping of general public wellbeing powers does not just imply that unpopular covid limits will end, he claimed. These curbs typically cripple community health’s potential to struggle other scourges.
In Missouri, condition legislators handed a legislation very last summertime limiting general public wellness powers. A judicial ruling in November even more chipped absent at regional overall health officials’ authority to problem covid constraints, expressing they were “dependent on the unfettered opinion of an unelected official.” Missouri Lawyer Standard Eric Schmitt — who is also managing for Senate — is suing schools to reduce mask mandates and in December created an electronic mail idea box exactly where dad and mom can send out concerns, images, and video clips that require mask carrying by college students.
Kelley Vollmar, government director of the well being division in Jefferson County, in eastern Missouri, said these actions have severely weakened her public overall health powers. The state laws, for illustration, requires her to get orders confirmed by the county board of wellbeing. But the orders should be reconfirmed just after 30 days, and Vollmar has to commit $2,000 advertising them in her local paper.
“You can not rule by committee,” Benjamin said. “That’s like telling the chief of police that they simply cannot make an arrest.”
The November judicial ruling stripped Vollmar and other community well being officials in the condition of the capacity to situation any orders involving infectious disorders. People ought to now arrive from elected officers previously mentioned them. That affects public overall health equipment like speak to tracing, isolation, and quarantine — not just for covid, but also for the other 134 communicable conditions she’s tasked with preserving the public from.
“The matters they are stripping powers of are points generally occurring in the qualifications,” she claimed.
Vollmar has witnessed a sharp increase in requests for vaccine exemptions for measles and other preventable infectious ailments — and fears what could come upcoming.
It doesn’t aid that Missouri has underfunded public health for many years — a 2020 KHN and AP investigation found general public health investing for every man or woman was $50 a yr in Missouri — a person of the bottom 10 states in the nation.
That is part of a suitable-wing system, said Democratic condition Sen. John Rizzo, minority flooring chief. “They actively go and split authorities, and then run their following marketing campaign about how federal government is damaged,” he said.
All the whilst, the vaccination charge towards covid in Missouri hovers all-around 55{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d}, with outliers like Pulaski County in the Ozarks beneath 21{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d}. But individuals who opposed Kauerauf took his statements that he wished to raise vaccination stages as a signal that he might be professional-mandate, inspite of his protestations normally.
Kauerauf declined to remark for this write-up.
Republican Gov. Mike Parson was outraged that his nominee had been blocked. “I’ve been a conservative Republican my full lifetime and opposite to what some Senators imagine, tarnishing a man’s character by feeding misinformation, repeating lies, and disgracing 35 many years of public wellbeing knowledge is not what it suggests to be conservative,” he tweeted.
Acquiring a point out health department leader to tackle all these troubles now could be almost not possible, explained former Kansas Town well being section head Dr. Rex Archer, who still left his Missouri-primarily based article final summer soon after 23 many years. He’d recommend any person who requested about the work not to invest in a property in the condition or shift their family members.
“What skilled applicant would want to threat coming below and then not get verified simply because the get together in power won’t even help their governor’s nomination?” he explained.
Moon’s not nervous. He believes the point out will uncover an anti-abortion, anti-mandate applicant whose positions he can abdomen. “We don’t want an individual coming in who has been component of a point out that experienced demanding processes and treatments for this virus, bringing them with them,” he told KHN, citing Kauerauf’s prior public wellness experience in Illinois.
And he stated he acquired roughly 1,000 e-mails encouraging his go to block the nomination, as well as help from dozens of protesters, like some from the Concerned Ladies for America of Missouri, which opposed Kauerauf’s appointment.
That’s terrifying to Vollmar, who reported that means Moon does not want a community health director — he wants a politician.
“Our greatest prospect for a better community overall health technique in Missouri lies in the arms of the silent the vast majority of our inhabitants that support science-based mostly choices,” she stated. “I pray they come across their voice before it is too late.”
KHN (Kaiser Wellbeing News) is a nationwide newsroom that provides in-depth journalism about health and fitness challenges. Collectively with Coverage Assessment and Polling, KHN is one particular of the a few main working packages at KFF (Kaiser Spouse and children Foundation). KFF is an endowed nonprofit organization delivering info on well being difficulties to the nation.
This tale can be republished for free of charge (specifics).