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November 14, 2022
3 min read
Sicat, J. CBD for obesity? Our patients are asking! Presented at: Overcoming Obesity 2022; Nov. 2-5; (hybrid meeting).
Disclosures:
Sicat reports being a part of the speaker’s bureau for Eli Lilly and Novo Nordisk, Inc.
Marijuana has implications for weight and metabolism — but perhaps not in the ways one might expect, according to a speaker at the 2022 Overcoming Obesity conference.
During the presentation, Jeff Sicat, MD, FACE, FOMA, a physician with the Virginia Weight and Wellness who specializes in medical weight loss, discussed how marijuana and cannabidiol (CBD) affect weight and metabolism.
Although there are some positive factors of cannabis, like euphoria, a sense of relaxation, heightened sensory perception, increased appetite and more, Sicat said there are some negative factors, including “the munchies,” acute weight gain, anxiety, distrust, panic, paranoia and more.
In the Controlled Substance Act of 1970, the U.S. government categorized marijuana as a schedule I substance, “meaning it was considered to have no acceptable medicinal use and was among the class of drugs having the highest potential for abuse.”
Today, medical marijuana is legal in 38 states, four territories and Washington, D.C., and recreational marijuana is legal in 19 states, two territories and Washington, D.C. Usage rates are up, too: NIH data from 2021 recorded historic highs in marijuana use among adults aged 19 to 30 years — 43{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} of people in this group reported use in the last year.
“This is happening,” Sicat said. “It’s interesting that this is not something that I regularly have asked my patients in the past, but this really opens my eyes of how many people are actually using cannabis nowadays.”
Marijuana being classified as a schedule I drug, he explained, “really precludes a lot of studies from happening.” With the available data, though, Sicat said he noticed an interesting trend, one that he coined the “marijuana paradox for obesity”: small, short-term studies showed increases in body weight, but long-term studies revealed that chronic marijuana use was actually associated with weight loss.
In fact, he said, “the higher the dose of marijuana over the years is associated with a lower body weight.”
“When you look at prospective studies where they look at over 30,000 people across the country and follow them for the course of 3 years, you see that those who smoke the most cannabis or use the most cannabis actually have the lowest body weight in a dose-dependent manner,” he said. “The more frequent that someone is actually using cannabis, they’ll lower their body mass index.”
Additionally, he said that data have shown women using cannabis heavily were about 50{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} less likely to be diagnosed with type 2 diabetes than non-cannabis users.
A report from the National Academies of Sciences, Engineering and Medicine showed substantial or conclusive evidence that cannabis is effective in adults for chronic pain as well as chemotherapy-induced nausea and vomiting, and can improve muscle spasticity syndromes in MS.
Cannabis plants have at least 100 plant-derived phytocannabinoids, including tetrahydrocannabinol (THC), delta 8 THC, CBD and more. CBD — the most common phytocannabinoid — is, by volume, the biggest part of the cannabis plant.
“What’s nice about it is that it does not have any psychotropic effects; it actually has a very wide range of potential pharmacological effects through different mechanisms,” Sicat said.
For example, there is an FDA-approved CBD product for pediatric intractable epileptic seizures.
“It turns out that CBD in high doses has actually been shown to actually reduce seizures by almost 50{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} in this very refractory population,” he said.
Despite the fact that trials did not fully investigate weight loss, data from these studies indicated greater weight loss from people who took CBD compared with those who took placebo, though he cautioned that only 20{b574a629d83ad7698d9c0ca2d3a10ad895e8e51aa97c347fc42e9508f0e4325d} of participants were adults.
Although CBD has shown to be “helpful for a lot of different things … from a diabetes perspective, we are uncertain.”
Sicat referenced a 2016 study published in Diabetes Care that assessed the impact of CBD and THC on people with type 2 diabetes.
“When you look at the data, what they found is that it actually had benefit in terms of several different hormones. There’s actually a hormone called resistin that’s made in the body fat, and resistin causes resistance to insulin. And when they gave CBD at these doses, it actually reduced resistin,” he said.
Sicat concluded that “further studies are needed to better evaluate the benefits of CBD and other phytocannabinoids on metabolic features.”
“In conclusion, I would just say, personally, I have found that putting this presentation together has sort of opened my eyes because I really never thought about the impact of how many of my patients are actually taking all these different phytocannabinoids, how many of them might be taking medical marijuana, different things like this. [It] just has not been something that I’ve really asked about a lot, but it makes me really think about inquiring much more commonly about that.”
In the latest yrs there is been a escalating desire in the use of cannabis — the two marijuana and CBD items — to help treat a amount of health and fitness disorders, which include gastrointestinal issues. Some hashish merchandise are promoted as a method …
An NC State epidemiologist is major a wide-ranging examine to master how environmental contaminants impact liver health in diverse populations. Cathrine Hoyo, a Goodnight Innovation Distinguished Chair, to start with started inspecting these connections to test a suspicion: When she labored at Duke University, she discovered …

Air pollution can lead to eczema flare-ups, a typical skin ailment that brings about itchiness  |  Photo Credit score: iStock Pictures



New Delhi: With the air finding hefty with pollutants, the hearts of people are receiving heavier with anxiety and stress of the mysterious. The dreadful air has been disrupting people’s lives by placing their health at an greater hazard of respiratory conditions, cardiovascular troubles, and other wellbeing troubles. But inside organs are not the only susceptible parts of the entire body. Pores and skin, the outer covering of the human system has been similarly vulnerable to the harmful outcomes of air pollution. With no respite in sight, it is essential to fork out heed to the difficulty at hand and fully grasp sure intricacies relating to the affect of air pollution on pores and skin health and ways to deal with the very same.
Situations Now electronic related with Dr Rinky Kapoor, Guide Skin doctor, Cosmetic Skin doctor & Dermato-Surgeon at The Esthetic Clinics to get an perception into the expanding menace of air pollution on pores and skin overall health.
Situations Now: What are some frequent pores and skin challenges that persons face thanks to air pollution?

Dr Rinky Kapoor: Our skin is the largest organ that interacts with the outdoors atmosphere. While our skin is a sturdy actual physical and chemical barrier towards environmental aspects, it is imperative to continue to keep in intellect that its potential is constrained. When exposed to environmental stresses like air pollution the pores and skin barrier operate gets disturbed and results in a variety of skin complications.
Air pollution can have an affect on the pores and skin in liquid, gas, and sound variety. The pollutants enter the entire body by way of sweat ducts, hair follicles, inhalation and many others. Air pollution brings about oxidated stress that qualified prospects to the generation of cost-free radicals that disturb quite a few natural functions of the skin main to issues such as:









Occasions Now: What sort of air pollutants damage the pores and skin the most?

Dr Rinky Kapoor: Air air pollution is everywhere. Several air pollutants harm the pores and skin in numerous means. Since most particles current in the air do not right permeate the pores and skin, they can trigger chemical reactions to the pores and skin diminishing the skin’s natural defence possible. Various pollutants that hurt the skin the most are:







Times Now: How can a person mitigate the adverse consequences of pollution on the pores and skin?

Dr Rinky Kapoor: The simple answer would be to transfer away from these spots but it is not basically possible. The ideal you can do for your skin is to protect it. You can’t modify the out of doors air or the indoors for that matter but what you can do is to choose care that your skin does not come in speak to with pollutants a lot.
Prevent the triggers that bring about air pollution and when you notice any pores and skin-related indicators then call your dermatologist for the appropriate corrective course of action. Right here are some points you can do everyday to overcome the adverse effects of air pollution on your pores and skin:









Situations Now: Do alterations in way of life, diet, or skincare assist?

Dr Rinky Kapoor: Of course, it does. Typical training, diet program and a good skincare schedule assistance in cleansing the skin and it also lets the skin breathe healthily. It is helpful to contain the following in your schedule alongside with the previously mentioned-stated skincare schedule.




Moments Now: What are some suggestions to keep healthier pores and skin amidst the expanding air air pollution?

Dr Rinky Kapoor: The additional conscious you are about your skincare the more healthy your pores and skin will be. Defend your pores and skin from airborne pollutants. Air pollution is not likely wherever shortly and thus the earlier you get started with far better skincare the less complicated it will be to deal with the consequences. Use components that incorporate merchandise that have been extensively examined for popular toxin air pollution and contain antioxidants. Speak to your skin expert about your problems and what items will match your skin form.
It is also fully worthy of it to spend in high-excellent air masks, air purifiers, and ventilators at home. Prevent places with hefty pollution and community smoking cigarettes rooms. If you are uncovered to such an setting then make positive you use a cleansing wipe and the skin as quickly as you get absent from there and cleanse the pores and skin properly. Minor methods each working day will go a prolonged way in maintaining your pores and skin balanced and youthful-looking at all instances.
Disclaimer: Suggestions and strategies stated in the article are for general information purpose only and need to not be construed as expert health-related assistance. Normally consult with your health practitioner or a dietician before beginning any conditioning programme or producing any alterations to your eating plan.